Structural Biology brings molecules to life in 3D so that we can unpick how they form, work, and interact. It has led to many new insights into how different molecules in the human body keep us healthy, and prompted new disease treatments that modify malfunctioning molecules, such as Tamiflu used to treat influenza, and numerous structure-based drugs that combat HIV. The Rosalind Franklin Institute’s ‘Structural Biology theme aims to remove this bottleneck by revolutionising how molecule samples are produced, stabilised, delivered and transferred.

The Role The Rosalind Franklin Institute (the Franklin) is a National Research Centre, funded by the UK government through UK Research and Innovation (UKRI), dedicated to bringing about transformative changes in life science through interdisciplinary research and technology. The Electrifying Science grants from the Welcome Trust and the Amplus project funded by EPSRC both aim to develop new instrumentation for life science. In addition to state-of-the-art instruments, the institute houses and develops new technology, and the focus of this role is to disseminate these applications and developments via training and publication. The Franklin is working closely with microscope manufacturers (i.e., Thermofisher Scientific Jeol), national facilities (i.e., CCP-EM, eBiC) and houses an internal Artificial Intelligence and Informatics theme. The Franklin is seeking to recruit two Electron Microscopy Application experts (one cryo-FIB/SEM and one cryo-ET) within the Structural Biology theme of Rosalind Franklin Institute. Your role will be to enable the use of the state-of-the-art microscopy instrumentation as we as newly developed approaches for image acquisition and/or post-processing analysis for either cryo-electron tomography (cryo-ET) or dual beam FIB/SEM. As an application expert, we expect the candidate to work closely with the development teams (hardware & software, industry and in-house) to provide user requirements/ specifications and feedback throughout the development cycle.

Your primary task will be to utilize either the dual-beam FIB/SEM or TEM in the most efficient, up-to-date manner for data collection, including ensuring that the instruments’ application software’s are compatible and an optimal workflow is implemented. You will also be responsible for training users. You will work closely with the instrument managers and scientist leads, to maintain up-to-date protocols and safety information and be an active member in the development of the workflow. Finally, you will disseminate the newly developed techniques and/or protocols via publication, internal communication and/or conferences.


You will:

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    • Engage with the cross-disciplinary development teams to successfully implement the newest application/data processing software packages.
    • Be constantly the leading edge in new applications and image acquisition protocols.
    • Work in collaboration with the development teams and scientists to test the in-development software and hardware.
    • Document and train fellow scientists on the data collection and data processing pipeline(s).
    • Provide specifications and feedback to improve user experience.
    • Communicate and disseminate protocols through publications and presentations.

    Before submitting your application please ensure you read the Job Information Pack for full details of this role by clicking on the attachment at the bottom of this page.

    About us

    The Rosalind Franklin Institute is a new national Research Centre, funded by the UK government through UK Research and Innovation, dedicated to bringing about transformative changes in life science through interdisciplinary research and technology.

    Location: The Franklin is based in Harwell Campus, UK’s innovation hub and well-established as one of the leading science and innovation campuses in Europe.

    At the Rosalind Franklin Institute we welcome applications from all around the world!

    Closing date: Sunday 19th February 2023.

    Applicants should refer to our Candidate Privacy Policy

    Area Scientific

    Location Harwell

    Type of Post Full Time

    Period of appointment 3 years Fixed-Term Contract

    Salary £33,500 – £41,000 per annum, depending on experience (Higher at discretion, for exceptional candidate)

    Closing Date 19/02/2023

    Ref No 10255


    Job Pack

    (PDF, 1077.49kb)

    The Rosalind Franklin Institute


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